Which medication can be used to treat neuroleptic akathisia?

Propranolol is effective in treating neuroleptic akathisia, which is a condition characterized by an inner restlessness and an uncontrollable need to be in constant motion. Akathisia is often a side effect associated with antipsychotic medications due to their dopaminergic blockade in the brain.

The therapeutic action of propranolol stems from its beta-adrenergic antagonist properties. It can help alleviate the symptoms of akathisia by reducing adrenergic excess, which may contribute to restlessness and anxiety. Propranolol has been shown in various studies to provide symptomatic relief for patients experiencing akathisia related to antipsychotic treatment.

Other options, while beneficial for different conditions, do not specifically target the mechanisms or symptoms associated with akathisia. Amantadine is more commonly used for parkinsonism and drug-induced extrapyramidal symptoms but is not as effective for akathisia. Dopamine agonists may potentially worsen akathisia rather than alleviate it due to further dopaminergic stimulation. Selective serotonin reuptake inhibitors (SSRIs) are primarily used for mood disorders and may not effectively address the symptoms of akathisia.

Thus, propranolol stands out as the preferred treatment option for