Which laboratory findings are indicative of primary hyperaldosteronism?

Primary hyperaldosteronism, also known as Conn's syndrome, is characterized by the excessive production of aldosterone, typically due to an adrenal adenoma or bilateral adrenal hyperplasia. The condition leads to a specific set of laboratory findings.

In primary hyperaldosteronism, there is an increase in sodium reabsorption, which often contributes to hypertension. Concurrently, increased aldosterone causes increased potassium excretion, leading to hypokalemia (low potassium levels). Therefore, a combination of low potassium and high sodium is indicative of this condition.

That’s why low potassium and high sodium levels in the laboratory findings align with the physiological changes occurring in primary hyperaldosteronism. This understanding of the relationship between aldosterone secretion and electrolyte imbalances is crucial for recognizing and diagnosing this endocrine disorder effectively.