Which hormone levels are elevated in a Leydig cell tumor?

Study for the USMLE Step 2 CK Exam. Prepare with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

In a Leydig cell tumor, which arises from the interstitial cells of the testes that produce testosterone, there is a significant increase in testosterone levels. These tumors often lead to hyperproduction of testosterone, which may subsequently result in increased estrogen levels as well, either due to peripheral conversion or direct secretion, especially if the tumor is large.

Leydig cell tumors can present with symptoms related to excess testosterone, which might include early virilization in prepubertal boys or gynecomastia and sexual dysfunction in adults due to the imbalance of sex hormones. The increased testosterone can also lead to some aromatization into estrogen, resulting in elevated estrogen levels.

Thus, the correct answer identifies elevated levels of both testosterone and estrogen associated with Leydig cell tumors.

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