Which condition is associated with hepatitis and peripheral neuropathy requiring pyridoxine supplementation?

Isoniazid (INH) is an antibiotic used primarily for the treatment of tuberculosis. One of the known side effects of isoniazid is its ability to interfere with vitamin B6 (pyridoxine) metabolism. This interaction can lead to peripheral neuropathy, as vitamin B6 is crucial for proper nerve function.

The mechanism involves isoniazid binding to the enzyme pyridoxal kinase, which reduces the levels of pyridoxal phosphate, the active form of vitamin B6. This depletion can result in neurological symptoms, particularly peripheral neuropathy. To mitigate this side effect, patients receiving isoniazid are often given pyridoxine supplementation to maintain adequate levels of vitamin B6 and prevent the development of neuropathy.

Additionally, isoniazid can cause hepatotoxicity, leading to hepatitic symptoms, which further links this drug to both hepatitis and peripheral neuropathy. Therefore, the association between isoniazid, hepatitis, and peripheral neuropathy requiring pyridoxine supplementation is well established in clinical practice.