Which aminoglycoside is particularly known for ototoxicity?

Gentamicin is particularly known for its ototoxic effects, which can result in hearing loss or balance issues. Ototoxicity is a significant concern with aminoglycosides, and gentamicin has a well-documented risk associated with its use, especially at higher doses or with prolonged treatment.

Aminoglycosides work by interfering with bacterial protein synthesis, and while they are effective antibiotics for certain infections, their potential for causing damage to the inner ear (vestibular and auditory systems) distinguishes gentamicin among this class of drugs. Monitoring for auditory function in patients receiving gentamicin therapy is crucial, particularly for those who have pre-existing renal dysfunction or those who are concurrently receiving other ototoxic medications.

Other aminoglycosides, while they can also pose a risk of ototoxicity, do not have the same level of association as gentamicin, making it the standout choice in this context.