What tumors are associated with MEN type 1?

Multiple Endocrine Neoplasia type 1 (MEN1), also known as Wermer's syndrome, is characterized by the triad of pituitary adenomas, hyperparathyroidism due to parathyroid hyperplasia, and pancreatic endocrine tumors. This syndrome arises from mutations in the MEN1 gene which encodes for the protein menin, involved in tumor suppression.

Pituitary tumors in MEN1 can secrete various hormones, often leading to conditions such as acromegaly if they’re growth hormone-secreting, or Cushing's disease if they produce adrenocorticotropic hormone (ACTH). Parathyroid tumors lead to excessive parathyroid hormone (PTH) production, resulting in primary hyperparathyroidism, a common manifestation of MEN1. Pancreatic tumors, or gastrinomas, are notable for causing Zollinger-Ellison syndrome, characterized by recurrent peptic ulcers.

In contrast, while medullary thyroid tumors are associated with MEN2, neuroendocrine tumors can be found in other endocrine neoplasia syndromes but are not specific to MEN1. Adrenal tumors may be seen in various contexts but are not a hallmark of MEN1. Understanding these associations is crucial for recognizing the clinical