What is the role of Mesna in the treatment related to cyclophosphamide and ifosfamide?

Mesna is a chemoprotective agent primarily used to prevent the urotoxic side effects that can occur with the administration of cyclophosphamide and ifosfamide, especially in high doses. These medications can cause hemorrhagic cystitis due to the formation of toxic metabolites, such as acrolein, which can irritate the bladder lining. Mesna functions by binding to these toxic metabolites in the urine, thereby neutralizing their harmful effects and preventing damage to the bladder.

In this context, the correct role of Mesna is clearly demonstrated through its protective mechanism, which significantly reduces the risk of bladder issues associated with cyclophosphamide and ifosfamide treatment.