What is the causative agent of Cat-scratch disease?

Cat-scratch disease is caused by a bacterial infection from Bartonella henselae, which is primarily transmitted through scratches or bites from infected cats, particularly kittens. The infection typically presents with localized lymphadenopathy, fever, fatigue, and sometimes a papule at the site of the scratch. Diagnosis is often made clinically, and serological testing can help confirm the presence of antibodies against Bartonella henselae.

Bartonella quintana is another species in the Bartonella genus, but it is more commonly associated with trench fever and is transmitted by lice, not cats. Escherichia coli and Staphylococcus aureus are both pathogens that can cause a wide range of infections, but they are not related to cat-scratch disease. Escherichia coli is known for gastrointestinal infections, while Staphylococcus aureus is associated with skin infections, endocarditis, and other conditions but has no role in the pathogenesis of cat-scratch disease. Understanding the specific causative agent of cat-scratch disease is crucial for diagnosis and management, making recognition of Bartonella henselae important in clinical practice.