What is a well-known skin change associated with Cushing's syndrome?

Cushing's syndrome is characterized by prolonged exposure to elevated levels of cortisol, which leads to various physiological changes in the body, including notable skin changes. One of the hallmark dermatologic manifestations of this condition is thinning of the skin.

The mechanism behind skin thinning involves catabolic effects induced by excess cortisol. Cortisol diminishes collagen production and disrupts the skin's structural integrity, making it more fragile. This results in a fine, atrophic appearance of the skin, which can be easily damaged, leading to increased susceptibility to bruising and injury. Patients may also notice easy tearing and the presence of new or exaggerated wrinkles.

In addition to thinning, patients with Cushing's syndrome may exhibit other skin changes such as striae (purple streaks), increased pigmentation, and acne, but thinning of the skin remains a prominent feature that directly correlates with the underlying pathophysiology of excessive glucocorticoid exposure.

Other options, although potential skin findings in other contexts, do not directly correlate with the classic changes seen in Cushing's syndrome. Yellowing of the skin may indicate liver issues or jaundice, a rash on the trunk could be related to other dermatological conditions, and petechiae on the extremities, while they