What is a common symptom of Addison's disease?

In Addison's disease, which is characterized by an underproduction of adrenal hormones, particularly cortisol and aldosterone, fatigue is one of the hallmark symptoms. This fatigue is primarily due to the lack of cortisol, which plays a crucial role in energy metabolism and stress response. Patients may also experience muscle weakness and a general sense of low energy.

Other symptoms of Addison's disease may include weight loss, low blood pressure, changes in pigmentation, and salt cravings. The presence of chronic fatigue can significantly affect a patient's daily life and may be one of the first indicators leading to medical evaluation for adrenal insufficiency. In contrast, weight gain, hypertension, and hyperactivity are not typical manifestations of Addison's disease and are more commonly associated with excess adrenal hormone production, such as in Cushing's syndrome or other conditions. Hence, fatigue stands out as a common and telling symptom in the context of Addison's disease.