What is a common manifestation of parvovirus B19 infection in children?

Parvovirus B19 infection commonly presents in children with a characteristic "slapped cheek" rash, medically known as erythema infectiosum or fifth disease. This rash typically begins on the cheeks, giving the appearance of having been slapped, and is often followed by a lacy, reticular rash that can spread to the trunk and extremities. The rash is usually not itchy and often resolves on its own.

In addition to the distinctive rash, parvovirus B19 may also cause mild fever, headache, and flu-like symptoms, especially in the early stages of the infection. The "slapped cheek" appearance is a key clinical sign that helps in diagnosing this viral illness in a pediatric population.

The other choices listed do not represent typical manifestations associated with parvovirus B19. A vesicular rash on the palms is more characteristic of hand, foot, and mouth disease, while localized urticaria and generalized eczema are not specific to this viral infection and could arise from various other conditions or triggers.