What is a common indication of premature ovarian failure?

Premature ovarian failure (POF), also known as primary ovarian insufficiency, typically presents with a hormonal profile characterized by low estrogen and elevated follicle-stimulating hormone (FSH) levels. This occurs because the ovaries are unable to produce sufficient amounts of estrogen, leading to a reduction in negative feedback on the pituitary gland. As a result, FSH levels rise in an attempt to stimulate the ovaries.

The combination of low estrogen and high FSH (as seen in answer choice A) is a classic hormonal finding in premature ovarian failure. This condition can occur in women under the age of 40 and can be associated with symptoms such as irregular menstrual cycles, hot flashes, and infertility.

In the context of the other options, the presence of high estrogen paired with low FSH or LH would suggest an intact ovarian function with suppression of the pituitary, which does not occur in POF. Therefore, the combination found in option A accurately reflects the pathophysiology of premature ovarian failure.