What condition is characterized by eczema, thrombocytopenia, and recurrent infections?

The condition characterized by eczema, thrombocytopenia, and recurrent infections is Wiskott-Aldrich syndrome. This is an X-linked recessive immunodeficiency disorder primarily affecting males. The triad of symptoms seen in this syndrome includes eczema, which presents as an atopic dermatitis; thrombocytopenia, indicating a low platelet count that increases the risk for bleeding; and recurrent infections due to the underlying immunologic dysfunction, particularly affecting the humoral immunity and leading to an increased susceptibility to encapsulated bacteria.

The immunologic aspect of this disorder is tied to a mutation in the WAS gene, which is responsible for the proper functioning of T cells and platelets. In patients with Wiskott-Aldrich syndrome, the combination of these symptoms not only highlights the hematologic and dermatologic issues but also the increased risk for autoimmune diseases and malignancies later in life.

Other conditions listed do not present with this specific triad of symptoms. McCune-Albright syndrome is associated with fibrous dysplasia, café-au-lait spots, and endocrine abnormalities. Neurofibromatosis Type 2 primarily involves bilateral vestibular schwannomas and doesn't include eczema or thrombocytopenia. Peutz-Jeghers syndrome is characterized by gastrointestinal