What are two common depot antipsychotic medications?

Depot antipsychotic medications are long-acting formulations of antipsychotics that are administered via intramuscular injection, often providing therapeutic effects for several weeks or even months. This is particularly beneficial for patients with schizophrenia or other mental health disorders who may have adherence issues with daily oral medications.

Haloperidol and Fluphenazine are both first-generation antipsychotics and are among the most commonly used depot formulations. They have well-established efficacy in managing the symptoms of schizophrenia and acute mania, particularly in cases where consistent medication adherence is a concern.

Olanzapine and Quetiapine are second-generation antipsychotics, but they are not typically available in a long-acting injectable form. Chlorpromazine is an older antipsychotic but is less commonly used as a depot preparation these days. Risperidone does have a depot formulation, but the combination with Chlorpromazine does not represent a typical pairing for depot medications. Clozapine and Lurasidone do not typically come in depot forms either; Clozapine requires careful monitoring due to agranulocytosis risk and is usually given orally.

Thus, Haloperidol and Fluphenazine stand out as the most iconic representatives of depot ant