Peripheral neuropathy and ataxia can result from toxicity caused by what drug?

The drug responsible for causing peripheral neuropathy and ataxia in this scenario is isoniazid. Isoniazid, an antibiotic used primarily for the treatment and prevention of tuberculosis, can lead to neuropathy due to its mechanism of action, which interferes with the metabolism of vitamin B6 (pyridoxine). A deficiency in vitamin B6 is critical for the synthesis of neurotransmitters and proper nerve function, leading to symptoms such as peripheral neuropathy, which may manifest as numbness, tingling, and weakness in the limbs, as well as ataxia due to disrupted coordination.

Patients on isoniazid are often advised to take pyridoxine supplements to mitigate the risk of these neurological side effects. This association highlights the importance of monitoring treatment regimens and understanding the potential side effects of medications used in long-term therapies.