Cushing's syndrome involves which of the following symptoms?

Cushing's syndrome is characterized by the excessive production of cortisol, often due to a pituitary adenoma (Cushing's disease), adrenal tumors, or ectopic ACTH production. One of the hallmark symptoms of this condition is central obesity, which manifests as a redistribution of body fat to the abdomen, face, and neck, commonly referred to as "moon facies."

Additionally, individuals with Cushing's syndrome often present with other symptoms related to elevated corticosteroids, including hypertension, glucose intolerance or diabetes (often resulting in weight gain due to increased appetite), and thinning of the skin. Therefore, high corticosteroids and central obesity accurately describe the symptoms associated with Cushing's syndrome.

The other options present symptoms that do not align with the manifestations of Cushing's syndrome. For instance, hypoglycemia is not characteristic; instead, hyperglycemia is common due to cortisol's glucose-raising effects. Decreased cortisol and severe fatigue would be more indicative of conditions like adrenal insufficiency, not excess cortisol. Lastly, bone pain and hyperkalemia are typically associated with other endocrine disorders, such as primary adrenal insufficiency or certain types of adrenal tumors, rather than Cushing's syndrome.